Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/102359
Type: Artigo de periódico
Title: Molecular Characterization Of Hemoglobin α-d Chains From Geochelone Carbonaria And Geochelone Denticulata Land Turtles
Author: Melo M.B.
Bordin S.
Duarte A.S.S.
Ogo S.H.
Torsoni M.A.
Saad S.T.O.
Costa F.F.
Abstract: In order to help elucidate the evolution of α-globins, the complete cDNA and amino acid sequences of Geochelone carbonaria and Geochelone denticulata land turtles α-D chains have been described. In G. carbonaria, the cDNA is 539 bp with ATG start codon located at position 46, TGA stop codon at position 469 and AATAAA polyadenylation signal at position 520. In G. denticulata, the cDNA is 536 bp with ATG start codon located at position 46, TGA stop codon at position 469 and AATAAA polyadenylation signal at position 517. Both cDNAs codify 141 amino acid residues, differing from each other in only four amino acid residues. When comparing with human Hb α-chain, alterations in important regions can be noted: α110 Ala-Gly, α114 Pro-Gly, α117 Phe-Tyr and α122 His-Gln. There is a high homology between the amino acids of these turtles when compared with chicken α-D chains, progressively decreasing when compared with human, crocodile, snake, frog and fish α-chains. Phylogenetic analysis of α-D chains shows that those of turtles are closer to those of birds than to snakes and lizards. © 2002 Elsevier Science Inc. All rights reserved.
Editor: 
Rights: fechado
Identifier DOI: 10.1016/S1096-4959(02)00289-0
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0037304903&partnerID=40&md5=66bb9d08d5badfe4c91da7d16c3dd42c
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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