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Type: Artigo de periódico
Title: Costimulatory Molecule Expression On Leukocytes From Mice With Experimental Autoimmune Encephalomyelitis Treated With Ifn-β
Author: Hallal D.E.M.
Farias A.S.
Oliveira E.C.
Diaz-Bardales B.M.
Brandao C.O.
Protti G.G.
Pereira F.G.
Metze I.L.
Santos L.M.B.
Abstract: Interferon-β (IFN-β) is of benefit in the treatment of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), but the mechanisms by which it exerts this beneficial effect remain uncertain. The present data demonstrate that IFN-β therapy impairs the proliferative response to concanavalin A (ConA) and myelin basic protein (MBP), decreases expression of the CD80 molecule on leukocytes of treated mice, and may thereby impede the Th1 cell activation-promoting anergy in EAE. Moreover, IFN-β therapy increases expression of the CTLA4 molecule, which induces a counterregulatory Th2 response. The reduction of CD80 expression with concomitant increase of CTLA4 expression alters the course of EAE and may be useful as a monitor in therapy with IFN-β.
Rights: fechado
Identifier DOI: 10.1089/107999003766628133
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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