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|Type:||Artigo de periódico|
|Title:||Polymorphism At Position -174 Of Il-6 Gene Is Associated With Susceptibility To Chronic Periodontitis In A Caucasian Brazilian Population|
|Abstract:||Background: Interleukin-6 (IL-6) is a multifunctional cytokine that mediates inflammatory tissue destruction. A G to C substitution at position -174 in the promoter of IL-6 gene reduces in vitro transcription of IL-6. This polymorphism has been associated with inflammatory diseases like chronic arthritis. Objective: The aim of this study was to investigate the association between the IL-6-174 polymorphism and susceptibility to chronic periodontitis in Brazilians. Material and Methods: Eighty-four nonsmoking subjects over 25 years (mean age 42.4) were divided according to the severity level of periodontal disease: 36 healthy individuals (control group), 24 subjects with moderate and 24 with severe periodontitis. Genomic DNA was obtained from epithelial cells through a mouthwash with 3% glucose and scraping of oral mucosa. The samples were analyzed for IL-6-174 polymorphism using PCR-RFLP. The significance of the differences in the frequencies of the polymorphism in the control and groups with periodontitis was assessed by x 2 test (p<0.05). Results: Differences were found between control and groups with periodontitis in the genotype (p = 0.0036, OR = 3.0) and in the allele (p = 0.0838, OR = 1.9) frequencies. Conclusion: We concluded that the IL-6-174 polymorphism is associated with susceptibility to chronic periodontitis in the population studied.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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