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Type: Artigo de periódico
Title: Turbinatine, A Potential Key Intermediate In The Biosynthesis Of Corynanthean-type Indole Alkaloids
Author: Cardoso C.L.
Siqueira Silva D.H.
Tomazela D.M.
Verli H.
Young M.C.M.
Furlan M.
Eberlin M.N.
Da Silva Bolzani V.
Abstract: Extraction of the leaves of Chimarrhis turbinata has led to the isolation of turbinatine (1), a new corynanthean-type indole alkaloid, besides four known indole alkaloids, strictosidine, 5α-carboxystrictosidine, vallesiachotamine, and isovallesiachotamine. The structural determination of 1 was based on 1D and 2D spectroscopic data. An evaluation of the DNA-damaging activities of the isolates was performed by means of a bioassay using mutant strains of Saccharomyces cerevisiae, which indicated these compounds were weakly active.
Rights: fechado
Identifier DOI: 10.1021/np020547m
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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