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Type: Artigo de periódico
Title: D,l-cis-2,3-pyrrolidine Dicarboxylate Alters [3h]-l-glutamate Binding And Induces Convulsions In Mice
Author: Sinhorin V.D.G.
Carpes M.J.S.
Roehrs C.
Zimmer M.F.
Sauzem P.D.
Rubin M.A.
Correia C.R.D.
Mello C.F.
Abstract: This study investigated whether D,L-cis-2,3-Pyrrolidine dicarboxylate (D,L-cis-2,3-PDC), a new glutamate analogue, alters glutamate binding to cerebral plasma membranes and whether N-methyl-D-aspartate (NMDA) receptors are involved in the convulsant effect of this compound. D,L-cis-2,3-PDC reduced sodium-independent [3H]-L-glutamate binding to lysed membrane preparations from adult rat cortex and had no effect on sodium-dependent glutamate binding. Intracerebroventricular administration of D,L-cis-2,3-PDC (7.5-25 nmol/5 μl) induced generalized tonic-clonic convulsions in mice in a dose-dependent manner. The coadministration of MK-801 (7 nmol/2.5 μl), with D,L-cis-2,3-PDC (16.5 nmol/2.5 μl), fully protected the animals against D,L-cis-2,3-PDC-induced convulsions, while the coadministration of DNQX (10 nmol/2.5 μl) increased the latency to convulsions but did not alter the percentage of animals that had convulsions. These results suggest that D,L-cis-2,3-PDC-induced effects are mediated predominantly by NMDA receptors. © 2003 Elsevier Inc. All rights reserved.
Rights: fechado
Identifier DOI: 10.1016/j.pbb.2003.08.012
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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