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Type: Artigo de periódico
Title: Crotapotin Induced Modification Of T Lymphocyte Proliferative Response Through Interference With Pge2 Synthesis
Author: Garcia F.
Toyama M.H.
Castro F.R.
Proenca P.L.
Marangoni S.
Santos L.M.B.
Abstract: The immunosuppressive property has been demonstrated for the venom of the Crotalus durissus terrificus. Using a simple, novel method for obtaining crotapotin and phospholipase A2 isoforms from venom, it was possible to demonstrate that the addition of crotapotin to cultures of isolated lymphocytes resulted in a significant inhibition of the cellular proliferative response to Concanavalin A. This reduction in blastogenic response of lymphocytes is accompanied by a significant increase in the production of PGE2 by macrophages. This effect on the innate immune response suggests that this compound may modify the subsequent adaptative immune response. © 2003 Elsevier Ltd. All rights reserved.
Rights: fechado
Identifier DOI: 10.1016/S0041-0101(03)00198-3
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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