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|Type:||Artigo de periódico|
|Title:||Allyltrichlorostannane Additions To α-amino Aldehydes: Application To The Total Synthesis Of The Aspartyl Protease Inhibitors L-682,679, L-684,414, L-685,434, And L-685,458|
|Abstract:||The hydroxyethylene dipeptide isosteres L-682,679, L-684,414, L-685,434, and L-685,458 were synthesized in a few steps by a sequence involving an allyltrichlorostannane coupling with an α-amino aldehyde, followed by hydroboration of the corresponding 1,2-syn and 1,2-anti amino alcohols to give the diols, lactonization under TPAP conditions, lactone opening, and peptide coupling with the desired amine or dipeptide amide. The present synthetic approach represents a practical entry to a large range of other dipeptide isosteres.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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