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Type: Artigo de periódico
Title: Allyltrichlorostannane Additions To α-amino Aldehydes: Application To The Total Synthesis Of The Aspartyl Protease Inhibitors L-682,679, L-684,414, L-685,434, And L-685,458
Author: Dias L.C.
Diaz G.
Ferreira A.A.
Meira P.R.R.
Ferreira E.
Abstract: The hydroxyethylene dipeptide isosteres L-682,679, L-684,414, L-685,434, and L-685,458 were synthesized in a few steps by a sequence involving an allyltrichlorostannane coupling with an α-amino aldehyde, followed by hydroboration of the corresponding 1,2-syn and 1,2-anti amino alcohols to give the diols, lactonization under TPAP conditions, lactone opening, and peptide coupling with the desired amine or dipeptide amide. The present synthetic approach represents a practical entry to a large range of other dipeptide isosteres.
Rights: aberto
Identifier DOI: 
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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