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Type: Artigo de evento
Title: Determination Of Doxorubicin In Human Plasma By Excitation-emission Matrix Fluorescence And Multi-way Analysis
Author: Trevisan M.G.
Poppi R.J.
Abstract: Direct determination of doxorubicin (DXR), a cytotoxic anthracycline antibiotic, in human plasma was accomplished based on excitation-emission matrix (EEM) fluorescence measurements and multi-way chemometric methods based on parallel factor analysis (PARAFAC) and N-PLS. Several different procedures, such as residual analysis, core consistency diagnostic (CONCORDIA) and split-half analysis were employed to determine the correct number of factors in PARAFAC. These procedures converged to a choice of two factors, attributed to DXR and to the sum of two fluorescence species present in the plasma. Sample PARAFAC loadings were employed to build a regression model against concentration, resulting in a RMSECV of 0.060μgml-1. N-PLS using two factors produced a RMSECV of 0.045μgml-1. Figures of merit (FOM), such as sensitivity (SEN), selectivity (SEL) and limit of detection (LD) were determined for both PARAFAC and N-PLS. © 2003 Elsevier B.V. All rights reserved.
Rights: fechado
Identifier DOI: 10.1016/S0003-2670(03)00864-X
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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