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Type: Artigo de periódico
Title: Application Of (2,2′:6′,2″-terpyridyl) Copper(ii) Chloride Complex In Sensor Construction For Benzoyl Peroxide Determination In Pharmaceutical Samples
Author: Sotomayor M.D.P.T.
Dias I.L.T.
Neto G.D.O.
Kubota L.T.
Abstract: This work describes an alternative method for benzoyl peroxide (BP) determination in pharmaceutical samples, using an amperometric sensor based on a carbon paste modified with (2,2′:6′,2″-terpyridyl) copper(II) chloride complex [Cu(terpy)Cl]Cl·2H2O. The sensor presented the best response in 0.10moll-1 phosphate buffer solution (pH 7.0) applying a potential of -50mV versus SCE. In the optimized conditions the sensor showed a linear response range for BP from 0.9 to 5.0μgml -1. The response time for this sensor was 0.5s. The paste presented a stability of at least 6 months at room temperature. The precision of the measurements was 4.5%, expressed in term of relative standard deviation (R.S.D.) for n=5. A detailed study was carried out, in order to investigate the sensor response for some compounds contained in pharmaceutical formulations, such as carboxypolymethylene (carbopol® 940), triethanolamine, propyleneglycol, hydroxyethylcellulose (natrosol®), and no interference was observed with these compounds. The applicability of the sensor for BP determination was evaluated in pharmaceutical preparations, obtaining recovery averages of 98±1%. © 2003 Elsevier B.V. All rights reserved.
Rights: fechado
Identifier DOI: 10.1016/j.aca.2003.08.001
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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