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|Type:||Artigo de periódico|
|Title:||Experimental Paracoccidioides Brasiliensis Infection Increases Apoptotic Rate In Thymus|
|Author:||De Souza Souto P.C.|
|Abstract:||Many works have shown that immunosuppressive effects induced by systemic mycosis can be related with damage in primary lymphoid organs. Previous studies in our laboratory showed that Paracoccidioides brasiliensis was able to invade the thymus, inducing a severe atrophy. In this study, we evaluated the relationship between apoptosis and thymic alterations caused by P. brasiliensis in experimentally infected BALB/c mice. Histologically, it was observed a large number of cells showing nuclear condensation and karyorrhectic changes. By TUNEL technique, it was noticed an increase of apoptotic index during early stages of the infection. We believe that this augment could be involved in the immunosuppressive phenomenon frequently observed during the paracoccidioidomycotic infection in humans and experimental models.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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