Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/101823
Type: Artigo de periódico
Title: Experimental Paracoccidioides Brasiliensis Infection Increases Apoptotic Rate In Thymus
Author: De Souza Souto P.C.
Brito V.N.
Gameiro J.
Ricci L.C.
Cruz-Hofling M.A.
Verinaud L.
Abstract: Many works have shown that immunosuppressive effects induced by systemic mycosis can be related with damage in primary lymphoid organs. Previous studies in our laboratory showed that Paracoccidioides brasiliensis was able to invade the thymus, inducing a severe atrophy. In this study, we evaluated the relationship between apoptosis and thymic alterations caused by P. brasiliensis in experimentally infected BALB/c mice. Histologically, it was observed a large number of cells showing nuclear condensation and karyorrhectic changes. By TUNEL technique, it was noticed an increase of apoptotic index during early stages of the infection. We believe that this augment could be involved in the immunosuppressive phenomenon frequently observed during the paracoccidioidomycotic infection in humans and experimental models.
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Rights: fechado
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Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0141656526&partnerID=40&md5=cfd0a721b28b96ab5dd76c449a09ca42
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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