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Type: Artigo de periódico
Title: Aldos De Histocompatibilidade De Classe Ii Em Indivíduos Portadores De Leucemias Agudas, Ao Diagnóstico Class Ii Hla Alleles In Acute Leukemia Carriers
Author: Fukai R.
Kraemer M.
Abstract: In this study, weanalyzed 100 healthy control individuals, 30 individuals with acute myeloid leukemia (AML), and 15 individuals with acute lymphoid leukemia (ALL) from the population of Campinas, a city in the southeast of Brazil. Typification of class II HLA alleles (HLA-DRBI-5 e DQB1) was carried out using the DNA/PCR/SSP molecular method at medium resolution. DNA was extracted through a salting-out procedure of peripheral blood of each individual participating in the research. 13 alleles DRB1, 1 allele DFB3, 1 alleleDFB4, 1 allele DRB5, and 5 alleles DQB1 were quantified for a medium or generic resolution using the PCR/SSP technique for primers of "One Lambda". The result showed a positive association - suggesting susceptibility to AML and ALL - for patients presenting the HLA-DRB1*07 allele (p = 0.01, c 2 = 6.63, RR= 3.05) and the HLA-DRB1*07/DQB1*02 haplotype (p = 0.01, c 2=5.60, RR=2.84) regarding AML For ALL a positive association was found for the HLA-DRB1*03 (p = 0,008, c 2=6,8943, RR=4.4615) and HLA-DQB1*02 alleles (p=0.01, c 2=6.31, RR=4.06). Negative associations were found for the HLA-DQB1*03 allele (p = 0.0015, c 2 = 10.14, RR = 0.25) for both AML and ALL, and for HLA-DFB1*04 (p = 0.02, c 2 = 4.86, RR = 0.13) and DQB1*03 alleles (p = 0.003, c 2=8.47, RR=0.00), as well as the HLA-DRB1*041 DQB1*03 haplotype (p = 0.01, c 2 = 5.55, RR = 0.00). Results allow us to define the control population as miscellaneous Caucasoid and suggest a possible association of Class II-HLA-DRB1 and DQB1 allelesin the etiology of acute leukemia. However, data have to be confirmed in future studies with an increased number of cases and through other controlled studies.
Rights: aberto
Identifier DOI: 
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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