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|Type:||Artigo de evento|
|Title:||Freeze Drying Process: Real Time Model|
Filho II R.M.
De Toledo III E.C.V.
|Abstract:||Freeze drying is a separation process based on the sublimation phenomenon. This process has the following advantages: the material structure is maintained, moisture is removed at low temperature (reduce transport rates), increase the product stability during the stab, the fast transition moisturized to be dehydrated minimizes several degradation reaction. A mathematical model based on fundamental mass and energy balance equations have been developed, based in an existent model (LIAPIS & SADIKOGLU, 1997), and used to know the amount of water removed and amount of residual water. The developed model contains the freeze drying equations, which are solved by orthogonal collocation and polynomial approximation - Jacobi method. The results show that the dynamic mathematical model represents well the process. The model allows for extensive simulation to be made, so that it was possible to observe which are the design as well as operational variables with more significantly impact the system behavior. Due to the relatively large number of variables it was necessary to submit the process to an initial screening design The methodology of Plackett-Burman is a tool for this initial screening, since it makes possible to determine the influence of various factors with only a small number of trials, instead of using more extensive factorial design, which would furnish more complete information, but which involve unfeasible complexity. Using the method of factorial design it is possible to determine statistical models and acquire additional knowledge about the process, that is important for process control. The statistical equations are a good and simple option to obtain quickly answers easy to use models, however fully deterministic models could be used in the complex works of design and scale-up of the process.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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