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|Type:||Artigo de periódico|
|Title:||Attenuation Of Hypertension, Cardiomyocyte Hypertrophy, And Myocardial Fibrosis By β-adrenoceptor Blockers In Rats Under Long-term Blockade Of Nitric Oxide Synthesis|
De Azevedo A.P.
De Oliveira C.F.
De Luca I.M.S.
De Nucci G.
|Abstract:||The effects of propranolol and atenolol were investigated on arterial hypertension, cardiomyocyte hypertrophy, and ventricular ischaemic lesions induced by an 8-week treatment with the nitric oxide synthase inhibitor Nω-nitro-L-arginine methyl ester (L-NAME; 20 mg/rat per day) in Wistar rats. Propranolol and atenolol (30 mg/rat per day each) were given in the drinking water concomitantly to L-NAME. Treatment with L-NAME induced marked arterial hypertension and cardiomyocyte hypertrophy, both of which were significantly reduced by propranolol and atenolol. A marked repairing fibrosis was also observed in L-NAME-treated rats and this was significantly attenuated in animals receiving the β-blockers. In L-NAME group, 33% mortality was observed, whereas all the animals from the other groups survived. Our study demonstrates that propranolol and atenolol reduce arterial hypertension, cardiomyocyte hypertrophy and myocardial fibrosis induced by L-NAME, suggesting that β-blockers are of beneficial value in treatment of vascular and cardiac alterations caused by chronic nitric oxide deficiency.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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