Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/101339
Type: Artigo de periódico
Title: Influence Of Propofol And Etomidate On Rocuronium-induced Neuromuscular Block. Evaluation With Acceleromyography [influência Do Propofol E Do Etomidato No Bloqueio Neuromuscular Produzido Pelo Rocurônio. Avaliação Pela Aceleromiografia]
Author: Munhoz D.C.
Braga A.D.F.D.A.
Poterio G.M.B.
Abstract: Background and Objectives - Some hypnotics may interact with neuromuscular blockers and potentiate their effects. This study aimed at evaluating the influence of propofol and etomidate on rocuronium-induced neuromuscular block. ++Methods - Participated in this study 60 patients, physical status ASA I and II, scheduled for elective surgeries under general anesthesia, who were randomly distributed in two groups according to the hypnotic drug: Group I (propofol) and Group II (etomidate). All patients were premedicated with intramuscular midazolam (0.1 mg.kg -1), 30 minutes before surgery. Anesthesia was induced with propofol (2.5 mg.kg -1) or etomidate (0.3 mg.kg -1) preceded by alfentanil (50 mg.kg -1) and followed by rocuronium (0.6 mg.kg -1). Patients were ventilated under mask with 100% oxygen until achieving a decrease of 75% or more in the adductor pollicis muscle response amplitude. Neuromuscular function was monitored by accelerometry. The following parameters were evaluated: rocuronium onset (T 1≤ 25%); time for complete neuromuscular block; neuromuscular block degree at tracheal intubation; tracheal intubation conditions and hemodynamic effects. Results - Complete rocuronium -induced neuromuscular block onset times (in seconds) were: Group I (48.20 ± 10.85 s and 58.87 ± 10.73 s) and Group II (51.20 ± 13.80 s and 64.27 ± 18.55 s). Neuromuscular block degree at tracheal intubation was: Group I (77.50%) and Group II (76.96%). Tracheal intubation conditions were satisfactory in 100% of Group I patients and in 83.33% of Group II patients. There has been a significant decrease in mean blood pressure, followed by an increase after hypnotic injection, in both groups. Conclusions - Propofol and etomidate had a similar behavior regarding time for rocuronium -induced neuromuscular block and tracheal intubation conditions.
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Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0036856899&partnerID=40&md5=1bd142bd19ca34da28a7d79fdc96bdb5
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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