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|Type:||Artigo de periódico|
|Title:||The Stereochemistry Of The Addition Of Titanium Enolates Of N- Propionyl-oxazolidin-2-ones To 5- And 6-membered N-acyliminium Ions|
|Abstract:||The stereochemistry of the addition of the N-propionyl titanium enolates 2a and 2b to 5- and 6-membered 2-ethoxyearbamates 1a-f was investigated. The addition proceeded stereoselectively to afford the corresponding (2S,1'S)-2- substituted pyrrolidines as the major diastereoisomer. Despite the lack of reactivity between 2-ethoxypiperidine 1b and N-propionyl titanium enolates 2a and 2b, less bulky carbamate groups on 2-ethoxypiperidines 1d and 1f restored reactivity and the corresponding 2-substituted piperidines were obtained in moderate to good yields although with poor diastereoseleetion.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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