Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/101204
Type: Artigo de periódico
Title: Effect Of Toxin-g From Tityus Serrulatus Scorpion Venom On Gastric Emptying In Rats
Author: Bucaretchi F.
Vinagre A.M.
Chavez-Olortegui C.
Collares E.F.
Abstract: The effect of toxin-γ from Tityus serrulatus scorpion venom on the gastric emptying of liquids was studied in 176 young adult male Wistar rats (2-3 months of age) divided into subgroups of 8 animals each. Toxin-γ was injected iv at doses of 25, 37.5, 50 or 100 μg/kg and the effect on gastric emptying was assessed 30 min and 8 h later. A time-course study was also performed by injecting 50 μg of toxin-γ/kg and measuring the effect on gastric emptying at times 0.25, 0.5, 1, 2, 4, 8, 24 and 48 h post-venom. Each envenomed animal was paired with its saline control and all received a saline test meal solution containing phenol red (60 μg/ml) as a marker. Ten minutes after administering the test meal by gavage the animals were sacrificed and gastric retention was determined by measuring the residual marker concentration of the test meal. A significant delay in gastric emptying, at 30 min and 8 h post-venom, was observed only after 50 and 100 μg of toxin- γ/kg compared to control values. The responses to these two doses were significantly different after 8 h post-venom. Toxin-γ (50 μg/kg) significantly delayed the gastric emptying of liquids at all times studied, with a peak response at 4 h after toxin administration compared to control values. These results indicate that the iv injection of toxin-γ may induce a rapid, intense and sustained inhibition of gastric emptying 0.25 to 48 h after envenomation.
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Rights: aberto
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Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0032925181&partnerID=40&md5=cde6a6f79da8a94775109f0a6aa1487e
Date Issue: 1999
Appears in Collections:Unicamp - Artigos e Outros Documentos

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