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Type: Artigo de periódico
Title: Interferon β Modulates Experimental Autoimmune Encephalomyelitis By Altering The Pattern Of Cytokine Secretion
Author: Yasuda C.L.
Al-Sabbagh A.
Oliveira E.C.
Diaz-Bardales B.M.
Garcia C.A.A.
Santos L.M.B.
Abstract: The mechanism of action underlying the beneficial effect of IFNβ in Multiple Sclerosis is poorly understood. Experimental Autoimmune Encephalomyelitis (EAE) is the experimental model for Multiple Sclerosis; therefore, we investigated the effects of recombinant mouse IFNβ on the severity of EAE induced in SJL mice and on cytokine production by Th1 and Th2 lymphocytes. The results indicated that rmIFN β reduced the disease activity with an I.P. dosage of 10,000 U/day every other day, and successfully treated EAE mice revealed reduced mounts of IFN γ; no changes in the levels of IL4 were observed, although there was a significant increase in IL10 and TGFβ production. Beneficial effects on EAE are associated with inhibition of inflammatory cytokines and stimulation of anti-inflammatory cytokines.
Rights: fechado
Identifier DOI: 
Date Issue: 1999
Appears in Collections:Unicamp - Artigos e Outros Documentos

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