Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/100823
Type: Artigo de periódico
Title: Total Synthesis Of 10-deoxymethynolide, The Aglycon Of The Macrolide Antibiotic 10-deoxymethymycin
Author: Pilli R.A.
De Andrade C.K.Z.
Souto C.R.O.
De Meijere A.
Abstract: A short efficient total synthesis of 10-deoxymethynolide (2c), the aglycon of 10-deoxymethymycin (1c), has been accomplished in 16 steps and 12% overall yield from (S)-3-O-p-toluenesulfonyl-3-hydroxy-2-methylpropanal (15c). The synthesis features an expeditious preparation of (+)-5a, a synthetic equivalent of the Prelog-Djerassi lactonic acid, and the construction of a 12-membered lactone through an intramolecular Nozaki- Hiyama-Kishi coupling reaction.
Editor: 
Rights: fechado
Identifier DOI: 10.1021/jo9809433
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0032582735&partnerID=40&md5=a7a9b3666caab64ab955e29276e64e2f
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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