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Type: Artigo de periódico
Title: The Hyperinsulinemia Produced By Concanavalin A In Rats Is Opioid- Dependent And Hormonally Regulated
Author: Francisco-Doprado J.
Zambelli J.E.
Melo-Lima M.H.
Ribeiro-Dasilva G.
Abstract: The present study examines the effect of concanavalin A (Con A) on the blood insulin and glucose levels of rats. Male and female rats treated with Con A (62.5-500 μg/kg) for three days sowed a dose- and time-dependent hyperinsulinemia that listed more than 48 h. Male rats were more sensitive to Con A. Thus, 6 h after treatment with Con A the circulating insulin levels in male rats had increased by 85% (control: 10.2 ± 0.9 mU/l and Con A-treated: 10.3 ± mU/l) in females. An identical response was seen after 12 h. Con A (250 μg/kg) produced time-dependent hypoglycemia in both sexes but more pronounced in males. There was no correlation between the hypoglycemia and hyperinsulinemia described above. The Con A-induced hyperinsulinemia in rats of both sexes was abolished in gonadectomized animals, P<0.05) while testosterone (10 mg/kg, im) had no similar effect on intact female rats. Pretreating Con A-injected rats with opioid antagonists such as naloxone (1 mg/kg, sc) and naltrexone (5 mg/kg, sc) blocked the hyperinsulinemia produced by the lectin in males (control: +101 ± 17% vs naloxone-treated: +5 ± 14%, or naltrexone-treated: -23 ± 4.5%) and females (control: +86 ± 23% vs naloxone-treated: +21 ± 20%, or naltrexone-treated: -18 ± 11%). These results demonstrates that Con A increases the levels of circulating insulin in rats and that this response is opioid-dependent and hormonally regulated.
Rights: aberto
Identifier DOI: 
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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