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|Type:||Artigo de evento|
|Title:||Continuous Process For Large-scale Preparation Of Chiral Alcohols With Baker's Yeast Immobilized On Chrysotile Fibers|
|Author:||Wendhausen Jr. R.|
|Abstract:||Bioreductions of prochiral ketones in a continuous process were carded out in a Packed-bed-reactor with baker's yeast (Saccharomyces cerevisiae) immobilized on chrysotile fibers (IMBY). The performance of the reactor was observed for 30 days, under a constant dilution rate of 1.7 x 10-1 h-1 using ethylbenzoylformate as substrate. The steady state showed 2.9 x 10-2 g l-1 h-1 of productivity, 50% chemical yield, and 90% ee (enantiometric excess). Using ethylacetoacetate at the same dilution rate for 8 days, the steady state showed 65% chemical yield and 95% ee. No significant change on the IMBY integrity was observed. The results show that chrysotile is an excellent carrier for immobilization of baker's yeast (BY) cells to be used in the continuous process of bioreduction.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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