Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/100691
Type: Artigo de periódico
Title: Efficacy And Acceptability Of Two Monophasic Oral Contraceptives Containing Ethinylestradiol And Either Desogestrel Or Gestodene
Author: Halbe H.W.
De Melo N.R.
Bahamondes L.
Petracco A.
Lemgruber M.
De Andrade R.P.
Da Cunha D.C.
Guazelli C.A.F.
Baracat E.C.
Abstract: Objective To assess the contraceptive efficacy, cycle control and acceptability of two monophasic oral contraceptives containing either 30 μg ethinylestradiol plus 150 μg desogestrel or 30 μg ethinylestradiol plus 75 μg gestodene. Methods In a randomized, open-label, six-cycle, group-comparative, multicenter study performed in Brazil, pregnancies, cycle-control parameters, incidence of side-effects and the presence and severity of acne vulgaris were assessed, and blood pressure and body weight were measured at pretreatment and after one, three and six cycles of oral contraceptive use. Results Of the 595 women enrolled, 274 (86.7%) in the desogestrel/ethinylestradiol group and 227 (81.4%) in the gestodene/ethinylestradiol group completed the six cycles, providing data for 1753 and 1487 treatment cycles, respectively. Two pregnancies occurred, one of which (in the desogestrel/ethinylestradiol group) was attributed to user failure, whilst the other (in the gestodene/ethinylestradiol group) was thought to result from method failure. Cycle control was observed to be excellent; the incidences of irregular bleeding and minor side-effects were low in both groups and decreased after an initial increase in the first cycle. Pre-existing acne improved in both groups, whereas blood pressure and body weight remained essentially unchanged. Conclusions Both desogestrel/ethinylestradiol and gestodene/ethinylestradiol provide effective oral contraception with comparable cycle control and acceptability.
Editor: 
Rights: fechado
Identifier DOI: 
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0032151995&partnerID=40&md5=5ca77d60c1fc83a709d4c6f9c137a73a
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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