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Type: Artigo de periódico
Title: Determination Of Log P(app) For Drug Transfer To Microbial Cellular Systems Via The Taylor-aris Modified Diffusion Technique
Author: Montanari M.L.C.
Montanari C.A.
Veloso D.P.
Beezer A.E.
Mitchell J.C.
Volpe P.L.O.
Abstract: Partitioning is a key process in QSAR studies. Experimental and calculated log P can be obtained. In the search for new methods of obtaining partition coefficients we have modified the Taylor-Aris diffusion technique to allow the direct measurement of log P within the cell system itself. This technique is applied successfully to two different cell systems and an extrathermodynamic equation between log P for Escherichia coli and Saccharomyces cerevisiae seems to be a promising way of obtaining this parameter directly from them.
Rights: fechado
Identifier DOI: 
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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