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Type: Artigo de periódico
Title: Plasma Hydroxy Metronidazole/metronidazole Ratio In Anti-hcv Carriers With And Without Apparent Liver Disease
Author: Da Silva C.M.F.
David F.L.
Muscara M.N.
Sousa S.S.
Ferraz J.G.P.
De Nucci G.
Polimeno N.C.
Pedrazzoli Jr. J.
Abstract: Aims: To evaluate plasma hydroxy-metronidazole/metronidazole ratio as a dynamic liver function test in HCV-infected individuals with/without liver disease, in the absence of liver cirrhosis. Methods: Metronidazole was administered intravenously in healthy volunteers, asymptomatic anti-HCV-positive blood donors, and in chronic hepatitis C patients. Serology to HCV was determined by a second generation assay and confirmed by gelatin particle agglutination test using recombinant antigens C22-3 and C200. Plasma concentration of metronidazole and hydroxy-metronidazole was measured by high performance liquid chromatography in samples collected 5, 10, 20 and 30 min following the end of metronidazole infusion. Results: Chronic hepatitis C patients had abnormal liver enzymes, while healthy volunteers and anti-HCV-positive blood donors had normal liver biochemistry tests. Plasma metronidazole concentration was similar,in all groups studied. Plasma hydroxy-metronidazole/metronidazole ratio was significantly reduced in HCV-infected subjects, an effect observed 10 min after the end of drug infusion. Conclusions: Metronidazole clearance is impaired in anti-HCV-positive blood donors and chronic hepatitis C patients, indicating that HCV is capable of affecting liver function at early stages of the disease. The metronidazole clearance test can detect impaired liver function in HCV-infected individuals even in the absence of liver cirrhosis.
Rights: fechado
Identifier DOI: 10.1046/j.1365-2125.1998.00758.x
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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