Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/100543
Type: Artigo de periódico
Title: Endometrial Thickness And Oestradiol Concentration In Women With Bleeding Complaints During Use Of Norplant® Implants
Author: Faundes A.-.
Alvarez F.
Brache V.
Cochon L.
Abstract: The objective of this study was to measure oestradiol, progesterone and endometrial development among Norplant® implant users with bleeding complaints. Seventy-six volunteers complaining of prolonged/frequent bleeding were enrolled. Oestradiol, progesterone and endometrial thickness (assessed by vaginal ultrasound) were determined at that visit. Two thirds of the women had low oestradiol (< 50 pg/ml) and all except one had low progesterone concentrations (< 3 ng/ml). A total of 68% had a very thin endometrium (< 3 mm). A subgroup of 21 women were followed twice a week for 8 consecutive weeks. Oestradiol and progesterone concentrations remained low during the continuous bleeding episodes or short bleeding-free intervals (≤ 15 days), yet increased five- to sixfold (253.4 ± 142.2 pg/ml) in long bleeding-free intervals. Endometrial thickness remained thin irrespective of the differences in bleeding patterns and oestradiol. We conclude that Norplant® implant users with bleeding complaints are usually characterized by low oestradiol concentrations, absence of luteal activity and thin endometrium. A good correlation exists with increasing oestradiol concentrations and longer bleeding-free intervals, but this is not manifested by increased endometrial thickness. However, few subjects bleed with relatively high oestradiol concentrations, therefore a better understanding of the intimate disturbances related to endometrial bleeding in users of long-acting progestins is still pending.
Editor: 
Rights: fechado
Identifier DOI: 10.1093/humrep/13.1.188
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-2642703413&partnerID=40&md5=e57a0fae8f69a4ed7613cf01fa836a76
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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