Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/100521
Type: Artigo de periódico
Title: Prevalence Of The Mutation C677 → T In The Methylene Tetrahydrofolate Reductase Gene Among Distinct Ethnic Groups In Brazil
Author: Arruda V.R.
Siqueira L.H.
Goncalves M.S.
Von Zuben P.M.
Soares M.C.P.
Menezes R.
Annichino-Bizzacchi J.M.
Costa F.F.
Abstract: Vascular disease is a serious public health problem in the industrialized world, and is a frequent cause of death among the adult population of Brazil. Mild hyperhomocysteinemia has been identified as a risk factor for arterial disease, venous thrombosis, and neural tube defects. Individuals homozygous for the thermolabile variant of methylenetetrahydrofolate reductase (MTHFR-T) are found in 5-15% of the general population and have significantly elevated plasma homocysteine levels which represent one of the genetic risk factors for vascular diseases. We have analyzed the prevalence of individuals homozygous for the MTHFR-T in 327 subjects representing the three distinct ethnic groups in Brazil. The prevalence of homozygotes for the mutated allele MTHFR-T was high among persons of Caucasian descent (10%) and considerably lower among Black (1.45%) and Indians persons populations (1.2%). These data suggest that screening for the MTHFR-T allele should help in identifying individuals with a high risk of vascular disease among populations with a heterogeneous background.
Editor: 
Rights: fechado
Identifier DOI: 10.1002/(SICI)1096-8628(19980724)78:4<332::AID-AJMG5>3.0.CO;2-N
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0031902128&partnerID=40&md5=81c681772d37ac78f4783f9d574dc316
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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