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Type: Artigo de periódico
Title: Clinical Study Of The Efficacy And Tolerability Of Lansoprazole In The Management Of Duodenal Ulcer [estudo Clinico Sobre A Eficacia E A Tolerabilidade De Lansoprazol No Tratamento Da Ulcera Duodenal]
Author: Zaterka S.
De Magalhaes A.F.N.
Eisig J.N.
Costa Leite Carvalhaes A.A.
Chinzon D.
Navarro Rodriguez T.
Abstract: The present study aimed to evaluate the efficacy and tolerability of lansoprazole 30 mg once daily in healing duodenal ulcer in two Brazilian centers. Patients were evaluated on the basis of clinical and endoscopic criteria before treatment and two weeks after the beginning of treatment. The patients who were not healed (red or white scar: S1 or S2 according Sakitas's classification) were reevaluated 4 weeks after the beginning of treatment. Fifthy-eight patients completed the study. Endoscopic examination revealed that duodenal ulcer was healed (S1 or S2 according Sakitas's classification) 2 weeks after the beginning of treatment in 51 patients (87,9%). In the remaining seven patients (12,1%) the ulcer was healed at the end of treatment (4 weeks). Clinical symptoms (daytime epigastric pain, nocturnal epigastric pain, daytime heartburn, nocturnal heartburn, nausea, vomiting, post-prandial distention, anorexia, and dysphagia) were dramatically reduced two weeks after the beginning of treatment in terms of the number of patients presenting the symptom and the severity. The present study confirms the efficacy of lansoprazole in the treatment of duodenal ulcer. All patients who completed the study were healed. The adverse events reported were mild nature and were not considered related to the medication under study, not requiring discontinuation of treatment. With a marked efficacy lansoprazole is also safe.
Rights: fechado
Identifier DOI: 
Date Issue: 1998
Appears in Collections:Unicamp - Artigos e Outros Documentos

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