Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/100362
Type: Artigo de periódico
Title: Corticosteroids Inhibit Il-12 Production In Human Monocytes And Enhance Their Capacity To Induce Il-4 Synthesis In Cd4+ Lymphocytes
Author: Blotta M.H.
DeKruyff R.H.
Umetsu D.T.
Abstract: We examined the effects of corticosteroids on IL-12 production by human monocytes and on cytokine synthesis in T cells. To distinguish the effects of corticosteroids on the APC used to activate the T cell from direct effects of corticosteroids on the T cell, experiments were performed by exposing the APC and not the T cell to corticosteroids. We found that corticosteroids significantly inhibited the production in monocytes of IL-12, a cytokine that is extremely potent in enhancing IFN-γ and inhibiting IL-4 synthesis in T cells. We demonstrated that reduced production of IL-12 in corticosteroid-treated monocytes resulted in a decreased capacity of the monocytes to induce IFN-γ and an increased ability to induce IL-4 in T cells. These results suggest that although corticosteroids may be beneficial for the treatment of asthma or allergic disease due to direct inhibitory effects of corticosteroids on cytokine synthesis in T cells, chronic corticosteroid therapy may indirectly exacerbate the long-term course of allergic disease. This deleterious effect of corticosteroids would result from a limitation in IL-12 production in tissue monocytes and macrophages, which would enhance production of Th2 cytokines (which augment allergic disease), and would reduce production of Th1 cytokines (which attenuate allergic disease) in T cells that subsequently infiltrate the tissues.
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Rights: fechado
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Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0031570475&partnerID=40&md5=c626b6068c96cc9e7e74092d8549d666
Date Issue: 1997
Appears in Collections:Unicamp - Artigos e Outros Documentos

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