Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/100097
Type: Artigo de periódico
Title: Chemotherapeutic Treatments With Time Increasing Mutation Rate To Drug Resistance
Author: Boldrini J.L.
Costa M.I.S.
Abstract: A system of differential equations for the control of tumor growth cells in a cycle non-specific chemotherapy is analyzed. Spontaneously acquired drug resistance is taken into account by means of a mutation rate increasingly dependent on time. For general tumor growth and drug kill rates the optimal treatment consists of maximum allowable drug concentration throughout, supporting the conjecture that variable mutation rate to drug resistance does not basically alter the corresponding results of constant mutation rate.
Editor: 
Rights: fechado
Identifier DOI: 
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-3042877096&partnerID=40&md5=f2bf2426868281667f1f769358d83fb5
Date Issue: 1997
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.