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Type: Artigo de periódico
Title: Chemotherapeutic Treatments With Time Increasing Mutation Rate To Drug Resistance
Author: Boldrini J.L.
Costa M.I.S.
Abstract: A system of differential equations for the control of tumor growth cells in a cycle non-specific chemotherapy is analyzed. Spontaneously acquired drug resistance is taken into account by means of a mutation rate increasingly dependent on time. For general tumor growth and drug kill rates the optimal treatment consists of maximum allowable drug concentration throughout, supporting the conjecture that variable mutation rate to drug resistance does not basically alter the corresponding results of constant mutation rate.
Rights: fechado
Identifier DOI: 
Date Issue: 1997
Appears in Collections:Unicamp - Artigos e Outros Documentos

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