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Type: Artigo de periódico
Title: Ceftriaxone In The Treatment Of Spontaneous Bacterial Peritonitis: Ascitic Fluid Polymorphonuclear Count Response And Short-term Prognosis
Author: Mesquita M.A.
Balbino E.P.S.
Albuquerque R.S.
Carmona C.A.
Okubo B.T.
Lorena S.L.S.
Montes C.G.
Soares E.C.
Abstract: Background/Aims: In this study, ascitic fluid polymorphonuclear (PMN) response, short-term prognosis, and factors related to hospital mortality were investigated in 62 cases of spontaneous bacterial peritonitis ocurring in cirrhotic patients treated with Ceftriaxone (1g every 12 hours). Methodology: The diagnostic criteria for (SBP) were ascitic fluid PMN count < 250 cells/mm3 and no evidence of secondary peritonitis. Analysis of ascitic fluid samples were obtained on admission, and on the 4th and 10th days of antibiotic therapy. Results: The etiology of cirrhosis was alcohol in 63% of the cases, and 79.5% of patients belonged to Child-Pugh Class C. Ascitic fluid analysis showed positive cultures in 47% of the cases, and a marked decrease in PMN count during treatment (admission: 7762 ± 2837; 4th day: 388 ± 91; 10th day: 173 ± 59 cells/mm3). Ascitic PMN was < 250 cells/mm3 within 4 days of treatment in 33% of the cases. The hospital mortality rate was 24%, and was related to gastrointestinal hemorrhage, hepatic encephalopathy, renal failure and 4th day ascitic fluid PMN count. Conclusion: Ceftriaxone is a safe and effective option for the treatment of SBP.
Rights: aberto
Identifier DOI: 
Date Issue: 1997
Appears in Collections:Unicamp - Artigos e Outros Documentos

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