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Type: Artigo de periódico
Title: The Role Of Reactive Oxygen Species In Mitochondrial Permeability Transition
Author: Vercesi A.E.
Kowaltowski A.J.
Grijalba M.T.
Meinicke A.R.
Castilho R.F.
Abstract: We have provided evidence that mitochondrial membrane permeability transition induced by inorganic phosphate, uncouplers or prooxidants such as t-butyl hydroperoxide and diamide is caused by a Ca 2+-stimulated production of reactive oxygen species (ROS) by the respiratory chain, at the level of the coenzyme Q. The ROS attack to membrane protein thiols produces cross-linkage reactions, that may open membrane pores upon Ca 2+ binding. Studies with submitochondrial particles have demonstrated that the binding of Ca 2+ to these particles (possibly to cardiolipin) induces lipid lateral phase separation detected by electron paramagnetic resonance experiments exploying stearic acids spin labels. This condition leads to a disorganization of respiratory chain components, favoring ROS production and consequent protein and lipid oxidation.
Rights: aberto
Identifier DOI: 10.1023/A:1027335217774
Date Issue: 1997
Appears in Collections:Unicamp - Artigos e Outros Documentos

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