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Type: Artigo de periódico
Title: Cephalosporin C Production And Genetic Improvement Of The Fungus Acremonium Chrysogenum Based On Morphological Mutant Isolation
Author: Vialta A.
Catani C.F.
Junior R.B.
Azevedo J.L.
Abstract: C-10 strain of the fungus Acremonium chrysogenum produced about 1.5 g/l of cephalosporin C, a yield that was much lower than expected according to the literature. This discrepancy, confirmed by exhaustive tests, showed that C-10 strain lost its high cephalosporin C production ability, probably due to genetic events. Strain improvement, based on isolation of morphologically compact mutant colonies, confirmed that this is a useful procedure for isolation of strains with increased titer. About 2% of tested colonies produced significantly more cephalosporin C than the original strain.
Rights: aberto
Identifier DOI: 
Date Issue: 1997
Appears in Collections:Unicamp - Artigos e Outros Documentos

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