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|Type:||Artigo de periódico|
|Title:||Qsar Based On Biological Microcalorimetry. Iii Interaction Of M-alcoxyphenols And P-hydroxybenzoates With Escherichia Coli [estudos De Qsar Baseados Em Dados De Atividade Biológica Obtidos Por Microcalorimetria. Iii Interaçåo De M-alcoxifenóis E P-hidroxibenzoatos De Alquila Com Escherichia Coli]|
|Abstract:||QSAR studies based on flow microcalorimetric bioassay data for interaction of homologous series of m-alkoxyphenols and p-hydroxybenzoates with E. coli cells were carried out applying factorial design. Results for both series showed a linear relationship between log(dose)max and log Po/w. Analysis of these data allows the identification of contributions toward the derived bioactivity from the parent structures (the molecule minus n-CH2 groups present in the side-chain) and the lipophilic groups, CH2. These results are discussed with respect to drug quantitative structure-relationship.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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