Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/99287
Type: Artigo
Title: Insulin secretion in patients deficient in glucose-6-phosphate dehydrogenase
Title Alternative: 
Author: Alegre, S. M
Saad, Sara T. O
Delatre E.
Saad, M. J. A
Abstract: Intravenous (IVGTT) and oral glucose tolerance tests (OGTT) were carried out in 12 men with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and in 11 normal men. The race, the mean age and body mass index were similar in the G-6-PD deficient and in the normal men. No significant differences were demonstrated between mean plasma glucose levels in the G-6-PD deficient subjects and those in the normal men during IVGTT and OGTT. In contrast the insulin levels were significantly lower for the G-6-PD deficient subjects as compared to the controls at 30 minutes (P < 0.04) in the OGTT and at 1 min (P < 0.001), 3 min (P < 0.001), 5 min (P < 0.001) and 10 minutes (P < 0.002) in the IVGTT. All indexes of first phase insulin release were also significantly (P < 0.001) lower in G-6-PD deficient men. These results emphasize the metabolic importance of G-6-PD in the process of glucose induced insulin release.
Intravenous (IVGTT) and oral glucose tolerance tests (OGTT) were carried out in 12 men with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and in 11 normal men. The race, the mean age and body mass index were similar in the G-6-PD deficient and in the normal men. No significant differences were demonstrated between mean plasma glucose levels in the G-6-PD deficient subjects and those in the normal men during IVGTT and OGTT. In contrast the insulin levels were significantly lower for the G-6-PD deficient subjects as compared to the controls at 30 minutes (P < 0.04) in the OGTT and at 1 min (P < 0.001), 3 min (P < 0.001), 5 min (P < 0.001) and 10 minutes (P < 0.002) in the IVGTT. All indexes of first phase insulin release were also significantly (P < 0.001) lower in G-6-PD deficient men. These results emphasize the metabolic importance of G-6-PD in the process of glucose induced insulin release
Subject: Teste de tolerância a glucose
Insulina
Country: Alemanha
Editor: Georg Thieme Verlag
Citation: Hormone And Metabolic Research. , v. 23, n. 4, p. 171 - 173, 1991.
Rights: fechado
Identifier DOI: 10.1055/s-2007-1003644
Address: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2007-1003644
Date Issue: 1991
Appears in Collections:FCM - Artigos e Outros Documentos

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