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Type: Artigo de periódico
Title: Long-term Therapy With Deflazacort Decreases Myocardial Fibrosis In Mdx Mice
Author: Marques M.J.
Oggiam D.S.
Barbin I.C.C.
Ferretti R.
Santo Neto H.
Abstract: We evaluated the effects of long-term administration of de-flazacort (DFZ) on the progression of myocardial fibrosis in mdx mice. Mdx mice (6 months old) were treated with DFZ for 15 months. Myocardial fibrosis (MF) was evaluated by histomorphometric methods, and treated and untreated mdx mice of the same age (21 months) were compared. DFZ significantly decreased MF. We conclude that long-term therapy with DFZ is effective in slowing down the progression of fibrosis in the dystrophin-deficient heart. © 2009 Wiley Periodicals, Inc.
Citation: Muscle And Nerve. , v. 40, n. 3, p. 466 - 468, 2009.
Rights: fechado
Identifier DOI: 10.1002/mus.21341
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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