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Type: Artigo de periódico
Title: Contribution Of Nuclear Texture Analysis For The Differential Diagnosis Of Follicular Lesions Of The Thyroid: Comparison To Immunohistochemical Markers [contribuição Da Análise De Textura Do Núcleo Celular Para O Diagnóstico Diferencial De Lesões Foliculares Da Tireoide: Comparação Com Marcadores Imunoistoquímicos]
Author: Ferreira R.C.
Ward L.S.
Adam R.L.
Leite N.J.
Metze K.
de Matos P.S.
Abstract: Objective and methods: To investigate the utility of nuclear chromatin texture assessment in the differential diagnosis of follicular patterned lesions, by means of examining 76 samples previously submitted to the immunohistochemical protein analysis of HBME-1, CK-19 and galectina-3. Results: HBME-1 confirmed to be the most sensitive marker of malignancy. A series of morphometric, densitometric and texture variables were useful in the discrimination of the different types of follicular lesions. Among these variables, r2, a parameter related to the granularity of the nucleus presented the best accuracy, sensitivity, specificity and positive and negative predictive values, distinguishing benign from malignant lesions. Conclusion: The morphometric analysis of nuclear chromatin images may add accuracy to the differential diagnosis of follicular patterned lesions.
Citation: Arquivos Brasileiros De Endocrinologia E Metabologia. , v. 53, n. 7, p. 804 - 810, 2009.
Rights: aberto
Identifier DOI: 
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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