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Type: Artigo de periódico
Title: MRI volumetry shows increased anterior thalamic volumes in patients with absence seizures
Author: Betting, LE
Mory, SB
Lopes-Cendes, I
Li, LM
Guerreiro, MM
Guerreiro, CAM
Cendes, F
Abstract: The interaction between thalamus and cortex appears to be critical to the pathophysiology of idiopathic generalized epilepsies (IGEs). The objective of this study was to investigate thalamic volumes of a group of patients with IGEs using high-resolution MRI. Thalamic segmentation was performed by the same rater, who was unaware of the diagnosis. Thalamic volumes were divided into anterior half and posterior half. One hundred forty-seven patients were scanned (71 with juvenile myoclonic epilepsy, 49 with generalized tonic-clonic seizures only, and 27 with absence epilepsy). Subgroup analyses with corrections for multiple comparisons showed that, when compared with those of controls, anterior thalamic volumes were increased in patients with absence epilepsy and juvenile myoclonic epilepsy with absence seizures, but not in patients with generalized tonic-clonic seizures only and juvenile myoclonic epilepsy without absence seizures. Our results demonstrated that the anterior thalamus is structurally different in patients with IGEs and absence seizures as compared with patients with IGEs without absence seizures. (c) 2006 Elsevier Inc. All rights reserved.
Subject: idiopathic generalized epilepsies
magnetic resonance imaging
absence seizures
juvenile myoclonic epilepsy
Country: EUA
Editor: Academic Press Inc Elsevier Science
Citation: Epilepsy & Behavior. Academic Press Inc Elsevier Science, v. 8, n. 3, n. 575, n. 580, 2006.
Rights: fechado
Identifier DOI: 10.1016/j.yebeh.2006.02.002
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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