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Type: Artigo de periódico
Title: Liposomal-praziquantel: Efficacy against Schistosoma mansoni in a preclinical assay
Author: Frezza, TF
Gremiao, MPD
Zanotti-Magalhaes, EM
Magalhaes, LA
de Souza, ALR
Allegretti, SM
Abstract: Currently, schistosomiasis mansoni is treated clinically with praziquantel (PZQ). Nevertheless, cases of tolerance and resistance to this drug have been reported, creating the need to develop new drugs or to improve existing drugs. Considering the small number of new drugs against Schistosoma mansoni, the design of nanotechnology-based drug delivery systems is an important strategy in combating this disease. The aim of this study was to evaluate the activity of PZQ containing liposome (lip.PZQ) on S. mansoni, BH strain. Mice were treated orally with different concentrations of PZQand lip.PZQ30 and 45 days following infection. The number of worms, recovered by perfusion of the hepatic portal system, and the number of eggs found in the intestine and liver were analysed. Parasite egg counts were also performed. The most active formulation for all parameters was 300 mg/kg of lip.PZQ since as it decreased the total number of worms by 68.8%, the number of eggs in the intestine by 79%, and the number of hepatic granulomas by 98.4% compared to untreated controls. In addition, this concentration decreased egg counts by 55.5%. The improved efficacy of the treatment with lip.PZQ, especially when administered 45 days following infection, compared with the positive-control group (untreated) and the groups that received free PZQ can be explained by greater bioavailability in the host organism; the preferred target of lip.PZQis the liver, and lip.PZQis better absorbed by the tegument of S. mansoni, which has an affinity for phospholipids. (C) 2013 Elsevier B.V. All rights reserved.
Subject: Praziquantel
Schistosoma mansoni
In vivo assay
Country: Holanda
Editor: Elsevier Science Bv
Citation: Acta Tropica. Elsevier Science Bv, v. 128, n. 1, n. 70, n. 75, 2013.
Rights: fechado
Identifier DOI: 10.1016/j.actatropica.2013.06.011
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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