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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleTh1 biased response to a novel Porphyromonas gingivalis protein aggravates bone resorption caused by this oral pathogenpt_BR
dc.contributor.authorLesheru, Opt_BR
dc.contributor.authorKashino, SSpt_BR
dc.contributor.authorGoncalves, RBpt_BR
dc.contributor.authorSuzuki, Npt_BR
dc.contributor.authorOnodera, Mpt_BR
dc.contributor.authorFujimura, Apt_BR
dc.contributor.authorSasaki, Hpt_BR
dc.contributor.authorStashenko, Ppt_BR
dc.contributor.authorCampos-Neto, Apt_BR
unicamp.authorLesheru, Onir Kashino, Suely S. Sasaki, Hajime Stashenko, Philip Campos-Neto, Antonio Forsyth Inst, Dept Cytokine Biol, Boston, MA 02115 USApt_BR
unicamp.authorLesheru, Onir Campos-Neto, Antonio Boston Univ, Sch Dent Med, Dept Oral Biol, Boston, MA 02215 USApt_BR
unicamp.authorGoncalves, Reginaldo B. Univ Estadual Campinas, Piracicaba Sch Dent, Sao Paulo, Brazilpt_BR
unicamp.authorSuzuki, Noriyuki Tokyo Med & Dent Univ, Grad Sch, Tokyo, Japanpt_BR
unicamp.authorOnodera, Masao Fujimura, Akira Iwate Med Univ, Sch Dent, Dept Oral Anat 1, Morioka, Iwate 020, Japanpt_BR
dc.subjectProphyromonas gingivalispt_BR
dc.subjectTh1 responsept_BR
dc.subjectbone resorptionpt_BR
dc.subject.wosEarly-onset Periodontitispt_BR
dc.subject.wosCell-expression Cloningpt_BR
dc.subject.wosCytokine Profilespt_BR
dc.description.abstractIn previous studies we showed that biasing the immune response to Porphyromonas gingivalis antigens to the Th1 phenotype increases inflammatory bone resorption caused by this organism. Using a T cell screening strategy we identified eight P. gingivalis genes coding for proteins that appear to be involved in T-helper cell responses. In the present study, we characterized the protein encoded by the PG_1841 gene and evaluated its relevance in the bone resorption caused by P. gingivalis because subcutaneous infection of mice with this organism resulted in the induction of Th1 biased response to the recombinant PG1841 antigen molecule. Using an immunization regime that strongly biases toward the Th1 phenotype followed by challenge with P. gingivalis in dental pulp tissue, we demonstrate that mice pre-immunized with rPG1841 developed severe bone loss compared with control immunized mice. Pre-immunization of mice with the antigen using a Th2 biasing regime resulted in no exacerbation of the disease. These results support the notion that selected antigens of P. gingivalis are involved in a biased Th1 host response that leads to the severe bone loss caused by this oral pathogen. (C) 2008 Elsevier Masson SAS. All rights
dc.relation.ispartofMicrobes And Infectionpt_BR
dc.relation.ispartofabbreviationMicrobes Infect.pt_BR
dc.publisherElsevier Science Bvpt_BR
dc.identifier.citationMicrobes And Infection. Elsevier Science Bv, v. 10, n. 6, n. 664, n. 672, 2008.pt_BR
dc.sourceWeb of Sciencept_BR
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