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Type: Artigo de periódico
Title: AHSP and beta-thalassemia: A possible genetic modifier
Author: dos Santos, CO
Costa, FF
Abstract: The identification of defectives genes underlying inherited diseases has made it clear that patients with the same genotype can have variable clinical expression. Suggestions proposing that the protein AHSP, a alpha-globin specific chaperone could influence disease severity in patients with beta-thalassemia, an inherited disorder characterized by a quantitative deficiency of beta-globin genes. This article presents a review of the AHSP gene structure, function and expression. A discussion of the AHSP gene knowledgments is presented with an overview of the possible genetic modifier function of AHSP on beta-thalassemia pathophisiology.
Subject: AHSP
Country: Inglaterra
Editor: Taylor & Francis Ltd
Citation: Hematology. Taylor & Francis Ltd, v. 10, n. 2, n. 157, n. 161, 2005.
Rights: fechado
Identifier DOI: 10.1080/10245330500067280
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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