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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleSubgingival biodiversity in subjects with uncontrolled type-2 diabetes and chronic periodontitispt_BR
dc.contributor.authorCasarin, RCVpt_BR
dc.contributor.authorBarbagallo, Apt_BR
dc.contributor.authorMeulman, Tpt_BR
dc.contributor.authorSantos, VRpt_BR
dc.contributor.authorSallum, EApt_BR
dc.contributor.authorNociti, FHpt_BR
dc.contributor.authorDuarte, PMpt_BR
dc.contributor.authorCasati, MZpt_BR
dc.contributor.authorGoncalves, RBpt_BR
unicamp.authorCasarin, R. C. V. Casati, M. Z. Univ Estadual Paulista, Div Periodont, Sao Paulo, Brazilpt_BR
unicamp.authorBarbagallo, A. Goncalves, R. B. Univ Laval, Grp Rech Ecol Bucale, Quebec City, PQ, Canadapt_BR
unicamp.authorCasarin, R. C. V. Meulman, T. Sallum, E. A. Nociti, F. H. Casati, M. Z. Univ Estadual Campinas, Dept Periodont, Piracicaba, Brazilpt_BR
unicamp.authorSantos, V. R. Duarte, P. M. Univ Guarulhos, Div Periodont, Guarulhos, Brazilpt_BR
dc.subjectperiodontal microbiotapt_BR
dc.subjectsubgingival plaquept_BR
dc.subject.wosCapnocytophaga Spp.pt_BR
dc.subject.wosAdult Periodontitispt_BR
dc.subject.wosGlycemic Controlpt_BR
dc.description.abstractBackground and Objective: There is a bidirectional relationship between periodontal disease and type-2 diabetes mellitus (DM). Inflammatory mediators may negatively affect glycemic control, and increased glucose levels and resultant glycation end-products may alter the host response against bacterial infection. However, no agreement has been reached regarding the effect of DM on periodontal subgingival microbiota. Therefore, the purpose of the present study was to compare the subgingival biodiversity in deep periodontal pockets of subjects with chronic periodontitis and either uncontrolled type-2 diabetes or no diabetes using 16S rRNA gene cloning and sequencing. Material and methods: Twelve subjects with uncontrolled type-2 diabetes (glycated hemoglobin > 8%) and eleven nondiabetic subjects presenting severe and generalized chronic periodontitis were selected. Subgingival biofilm from periodontal pockets > 5 mm were assessed using the 16S rRNA gene cloning and sequencing technique. Results: Significant differences were observed in subgingival microbiota between diabetic and nondiabetic subjects. Diabetic subjects presented higher percentages of total clones of TM7, Aggregatibacter, Neisseria, Gemella, Eikenella, Selenomonas, Actinomyces, Capnocytophaga, Fusobacterium, Veillonella and Streptococcus genera, and lower percentages of Porphyromonas, Filifactor, Eubacterium, Synergistetes, Tannerella and Treponema genera than nondiabetic individuals (p < 0.05). Moreover, some phylotypes, such as Fusobacterium nucleatum, Veillonella parvula, V. dispar and Eikenella corrodens were detected significantly more often in diabetic subjects than in nondiabetic subjects (p < 0.05). Conclusion: Subjects with uncontrolled type-2 diabetes and chronic periodontitis presented significant dissimilarities in subgingival biodiversity compared with nondiabetic
dc.relation.ispartofJournal Of Periodontal Researchpt_BR
dc.relation.ispartofabbreviationJ. Periodont. Res.pt_BR
dc.identifier.citationJournal Of Periodontal Research. Wiley-blackwell, v. 48, n. 1, n. 30, n. 36, 2013.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsordocumentnumberFAPESP [06/60314-5]pt
dc.description.provenanceMade available in DSpace on 2014-07-30T20:06:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:56:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
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