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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleSynthesis and characterization of a metal complex containing naringin and Cu, and its antioxidant, antimicrobial, antiinflammatory and tumor cell cytotoxicitypt_BR
dc.contributor.authorPereira, RMSpt_BR
dc.contributor.authorAndrades, NEDpt_BR
dc.contributor.authorPaulino, Npt_BR
dc.contributor.authorSawaya, ACHFpt_BR
dc.contributor.authorEberlin, MNpt_BR
dc.contributor.authorMarcucci, MCpt_BR
dc.contributor.authorFavero, GMpt_BR
dc.contributor.authorNovak, EMpt_BR
dc.contributor.authorBydlowski, SPpt_BR
unicamp.author.emailrpereira02@hotmail.compt_BR
unicamp.author.emailnormandrades@yahoo.com.brpt_BR
unicamp.author.emailniraldop@yahoo.com.brpt_BR
unicamp.author.emailfranksawaya@terra.com.brpt_BR
unicamp.author.emaileberlin@iqm.unicamp.brpt_BR
unicamp.author.emailcrismarcucci@naturalab.com.brpt_BR
unicamp.author.emailgmfavero@hotmail.compt_BR
unicamp.author.emailenovak@usp.brpt_BR
unicamp.author.emailspbydlow@usp.brpt_BR
unicamp.authorUniv Bandeirante Sao Paulo, Dept Pharm, Sao Paulo, Brazil Univ Estadual Campinas, UNICAMP, Inst Chem, Thomson Mass Spectrometry Lab, BR-13084971 Campinas, SP, Brazil Fundacao Prosangue Hemoctr Sao Paulo, Sao Paulo, SP, Brazilpt_BR
dc.subjectnaringin complexespt_BR
dc.subjectflavonoidpt_BR
dc.subjectanti-inflammatorypt_BR
dc.subjectantimicrobial and antioxidant activitiespt_BR
dc.subject.wosLipid-peroxidationpt_BR
dc.subject.wosFlavonoidspt_BR
dc.subject.wosRutinpt_BR
dc.subject.wosAssaypt_BR
dc.subject.wosQuercetinpt_BR
dc.subject.wosProliferationpt_BR
dc.subject.wosMacrophagespt_BR
dc.subject.wosInhibitionpt_BR
dc.subject.wosMechanismspt_BR
dc.subject.wosExtractpt_BR
dc.description.abstractThe antioxidant activity of flavonoids is believed to increase when they are coordinated with transition metal ions. However, the literature on this subject is contradictory and the outcome seems to largely depend on the experimental conditions. In order to understand the contribution of the metal coordination and the type of interaction between a flavonoid and the metal ion, in this study a new metal complex of Cu (II) with naringin was synthesized and characterized by FT-IR, UV-VIS, mass spectrometry (ESI-MS/MS), elemental analysis and H-1-NMR. The results of these analyses indicate that the complex has a Cu (II) ion coordinated via positions 4 and 5 of the flavonoid. The antioxidant, anti-inflammatory and antimicrobial activities of this complex were studied and compared with the activity of free naringin. The Naringin-Cu. (H) complex 1 showed higher antioxidant, anti-inflammatory and tumor cell cytoxicity activities than free naringin without reducing cell viability.pt
dc.relation.ispartofMoleculespt_BR
dc.relation.ispartofabbreviationMoleculespt_BR
dc.publisher.cityBaselpt_BR
dc.publisher.countrySuíçapt_BR
dc.publisherMolecular Diversity Preservation Intpt_BR
dc.date.issued2007pt_BR
dc.date.monthofcirculationJULpt_BR
dc.identifier.citationMolecules. Molecular Diversity Preservation Int, v. 12, n. 7, n. 1352, n. 1366, 2007.pt_BR
dc.language.isoenpt_BR
dc.description.volume12pt_BR
dc.description.issuenumber7pt_BR
dc.description.firstpage1352pt_BR
dc.description.lastpage1366pt_BR
dc.rightsabertopt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn1420-3049pt_BR
dc.identifier.wosidWOS:000250488100010pt_BR
dc.identifier.doi10.3390/12071352pt_BR
dc.date.available2014-11-19T05:42:58Z
dc.date.available2015-11-26T17:57:53Z-
dc.date.accessioned2014-11-19T05:42:58Z
dc.date.accessioned2015-11-26T17:57:53Z-
dc.description.provenanceMade available in DSpace on 2014-11-19T05:42:58Z (GMT). No. of bitstreams: 1 WOS000250488100010.pdf: 86957 bytes, checksum: b79ad384bf608cbed1076589c8435922 (MD5) Previous issue date: 2007en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:57:53Z (GMT). No. of bitstreams: 2 WOS000250488100010.pdf: 86957 bytes, checksum: b79ad384bf608cbed1076589c8435922 (MD5) WOS000250488100010.pdf.txt: 34454 bytes, checksum: c714df9f2a2d5d7870e1b037535dc546 (MD5) Previous issue date: 2007en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/74027pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/74027
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/74027-
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