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Type: Artigo de periódico
Title: Synthesis and biological activity of 6-formyl-oxamniquine derivative
Author: de Almeida, AE
de Souza, ALR
Allegretti, SM
Frezza, TF
Pinto, MC
Ferreira, AG
Chung, MC
Abstract: Schistosomiasis, an important disease in Brazil, is caused by a trematode of the genus Schistosoma, reaching millions of person in one of the most endemic region of this disease in the whole globe. The main goal of this work was to syntetize the 6-formyl-oxamniquine derivative and evaluate its biological activity. The 6-formyl-oxamniquine derivative was obtained by the oxidation of oxamniquine with MnO2, applying the CH2Cl2 as solvent at room temperature for 24 hours. The obtaintion of 6-formyl-oxamniquine derivative compound was confirmed by IT spectroscopy and C-13 NMR and H-1 NMR, presenting similar activity when compared to the commercial oxamniquine (Mansil (R)).
Subject: Schistosomiasis
Schistosoma mansoni
Country: Brasil
Editor: Univ Sao Paulo, Conjunto Quimicas
Citation: Revista Brasileira De Ciencias Farmaceuticas. Univ Sao Paulo, Conjunto Quimicas, v. 44, n. 4, n. 749, n. 754, 2008.
Rights: aberto
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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