Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/73455
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampClemente-Napimoga, Juliana Trindadept_BR
dc.typeArtigopt_BR
dc.titleThe indirect antinociceptive mechanism of 15d-PGJ(2) on rheumatoid arthritis-induced TMJ inflammatory pain in ratspt_BR
dc.contributor.authorNapimoga, M. H.pt_BR
dc.contributor.authorQuinteiro, M. S.pt_BR
dc.contributor.authorMesquita, K. P.pt_BR
dc.contributor.authorClemente-Napimoga, J. T.pt_BR
dc.subjectArtrite reumatóidept_BR
dc.subjectArticulação temporomandibularpt_BR
dc.subject.otherlanguageArthritis, Rheumatoidpt_BR
dc.subject.otherlanguageTemporomandibular jointpt_BR
dc.description.abstractInflammation of the temporomandibular joint (TMJ) induced by rheumatoid arthritis (RA) have resulted in persistent pain and caused distress to many patients. Considering that not all patients respond to traditional drugs therapy to RA and it has demonstrated that 15-deoxy-(Delta 12,14)-prostaglandin J(2) (15d-PGJ(2)) into TMJ has a potential peripheral antinociceptive effect, the aim of this study was to evaluate the peripheral effect of 15d-PGJ2 in RA-induced TMJ inflammatory hypernociception. Antigen-induced arthritis (AIA) was generated in rats with methylated bovine serum albumin (mBSA). RA-induced TMJ hypernociception was assessed by measuring the behavioural nociceptive responses. After behavioural experiments, the animals were terminally anaesthetized and periarticular tissues were removed and homogenized. The supernatants were used to evaluate the levels of tumour necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and keratinocyte-derived chemokine (KC) by enzyme-linked immunosorbent assay as well the expression of PKC epsilon and PKA by western blotting analysis. The intra-articular injection of mBSA, but not phosphate buffered saline (control), in immunized rats induced dose-and time-dependent behavioural nociceptive responses in which the peak of nociceptive responses were obtained by using 10 mu g/TMJ of mBSA after 24 h. Pretreatment with 15d-PGJ(2) (30, 100 and 300 ng/TMJ) inhibited the RA-induced TMJ inflammatory hypernociception. In addition, 15d-PGJ(2) reduced the RA-induced release of TNF-alpha, IL-1 beta and KC (p < 0.05) as well the expression of PKA and PKC epsilon (p < 0.05). In the present study, we demonstrated that 15d-PGJ(2) was able to reduce the RA-induced TMJ inflammatory hypernociception by an indirect mechanism. This antinociceptive effect is in part due to decrease of TNF-alpha, IL-1 beta and KC levels and PKA/PKC epsilon expression in the TMJpt
dc.relation.ispartofEuropean journal of painpt_BR
dc.relation.ispartofabbreviationEur. j. painpt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherJohn Wiley & Sonspt_BR
dc.date.issued2012pt_BR
dc.date.monthofcirculationSept.pt_BR
dc.identifier.citationEuropean Journal Of Pain. Wiley Periodicals, Inc, v. 16, n. 8, n. 1106, n. 1115, 2012.pt_BR
dc.language.isoengpt_BR
dc.description.volume16pt_BR
dc.description.issuenumber8pt_BR
dc.description.firstpage1106pt_BR
dc.description.lastpage1115pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1090-3801pt_BR
dc.identifier.eissn1532-2149pt_BR
dc.identifier.doi10.1002/j.1532-2149.2012.00114.xpt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/j.1532-2149.2012.00114.xpt_BR
dc.description.sponsorshipFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorshipFAPEMIG - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAISpt_BR
dc.description.sponsorship1FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorship1FAPEMIG - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAISpt_BR
dc.description.sponsordocumentnumberFAPESP [2011/00683-5]pt
dc.description.sponsordocumentnumberFundacao de Amparo a Pesquisa do Estado de Minas Gerais, Brazil [FAPEMIG PPM 097/09]pt
dc.description.sponsordocumentnumber2011/00683-5pt_BR
dc.description.sponsordocumentnumberPPM097/09pt_BR
dc.date.available2014-07-30T19:38:16Z
dc.date.available2015-11-26T17:51:10Z-
dc.date.accessioned2014-07-30T19:38:16Z
dc.date.accessioned2015-11-26T17:51:10Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T19:38:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2012. Added 1 bitstream(s) on 2019-02-27T18:38:36Z : No. of bitstreams: 1 000307342300011.pdf: 603216 bytes, checksum: 13347c41b2814cb144b96a36926da483 (MD5) Bitstreams deleted on 2020-05-14T20:38:36Z: 000307342300011.pdf,. Added 1 bitstream(s) on 2020-05-14T20:42:51Z : No. of bitstreams: 1 000307342300011.pdf: 481785 bytes, checksum: 712eee9e3668c8443a5ffeeac6154994 (MD5) Bitstreams deleted on 2020-06-04T12:47:44Z: 000307342300011.pdf,. Added 1 bitstream(s) on 2020-06-04T12:52:53Z : No. of bitstreams: 1 000307342300011.pdf: 1085155 bytes, checksum: 0cb1bd7f14684243568020270a85d426 (MD5)en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:51:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/73455
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/73455-
dc.contributor.departmentDepartamento de Ciências Fisiológicaspt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.identifier.source000307342300011-
dc.creator.orcid0000-0003-1068-3039pt_BR
dc.type.formArtigopt_BR
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