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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleSalivary Gland Tumors Immunohistochemical Study of EGF, EGFR, ErbB-2, FAS and Ki-67pt_BR
dc.contributor.authorIto, FApt_BR
dc.contributor.authorIto, Kpt_BR
dc.contributor.authorColetta, RDpt_BR
dc.contributor.authorGraner, Ept_BR
dc.contributor.authorde Almeida, OPpt_BR
dc.contributor.authorLopes, MApt_BR
unicamp.authorIto, Fabio A. Coletta, Ricardo D. Graner, Edgard de Almeida, Oslei P. Lopes, Marcio A. Univ Estadual Campinas, Dept Semiol & Oral Pathol, Piracicaba Dent Sch, BR-13414903 Piracicaba, SP, Brazilpt_BR
unicamp.authorIto, Kazuhiro Antonio Prudente Hosp, Londrina Canc Inst, Londrina, Parana, Brazilpt_BR
dc.subjectsalivary gland cancerpt_BR
dc.description.abstractOBJECTIVE: To analyze the expression of ErbB-1 (Her-1 or EGFR), ErbB-2 (Her-2 or neu), ErbB-3 (Her-3) and ErbB-4 (Her-4) and their correlation in 3 different types of salivary gland tumors. STUDY DESIGN: Immunohistochemical expression of epidermal growth factor (EGF), EGFR, ErbB-2, fatty acid synthase (FAS) and Ki-67 were analyzed in 41 pleomorphic adenoma (PA), in 30 mucoepidermoid carcinoma (MEC) and in 30 adenoid cystic carcinoma (ACC) and correlated with their histologic patterns. RESULTS: EGF was more common in MEC and PA, but MEC had a higher percentage of strongly positive cases. EGFRc and EGFRm were both more frequent in MEC and ACC. Higher scores of ErbB-2c were observed in PA, followed by MEC and ACC. In contrast, higher scores of ErbB-2m were more common in MEC as compared to ACC and PA. FAS was most commonly found in PA and MEC. Moreover, MEC showed the highest percentage of strongly positive cases. Ki-67 was higher in MEC and ACC than in PA. From a correlation of immunomarkers with the histologic patterns, it was observed that cribriform ACC presented more expression of EGFR and high grade MEC showed a higher percentage of ErbB-2, FAS and Ki-67. CONCLUSION: EGF, EGFR, ErbB-2 and FAS were commonly found and seem to be important in the tumorigenesis of salivary gland tumors, particularly in MEC. (Anal Quant Cytol Histol 2009;31:280-287)pt
dc.relation.ispartofAnalytical And Quantitative Cytology And Histologypt_BR
dc.relation.ispartofabbreviationAnal. Quant. Cytol. Histol.pt_BR
dc.publisher.citySt Louispt_BR
dc.publisherSci Printers & Publ Incpt_BR
dc.identifier.citationAnalytical And Quantitative Cytology And Histology. Sci Printers & Publ Inc, v. 31, n. 5, n. 280, n. 287, 2009.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipNational Counsel of Technological and Scientific Developmentpt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsordocumentnumberFAPESP [03/12658-9]pt
dc.description.provenanceMade available in DSpace on 2014-07-30T18:39:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2009en
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