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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleOsteolytic lesions as a presenting sign of acute myeloid leukemiapt_BR
dc.contributor.authorLima, CSPpt_BR
dc.contributor.authorNeto, JVPpt_BR
dc.contributor.authorDa Cunha, MLpt_BR
dc.contributor.authorVassallo, Jpt_BR
dc.contributor.authorCardinalli, IApt_BR
dc.contributor.authorDe Souza, CApt_BR
unicamp.authorUNICAMP, Hematol & Hemotherapy Ctr, BR-13081970 Campinas, SP, Brazilpt_BR
dc.subjectacute myeloid leukemiapt_BR
dc.subjectosteolytic lesionspt_BR
dc.subjectimmunohistochemistrypt_BR
dc.subjectcomputed tomography scanpt_BR
dc.subjectbone scintygraphy scanpt_BR
dc.subject.wosAcute Megakaryoblastic Leukemiapt_BR
dc.subject.wosGranulocytic Sarcoma Chloromapt_BR
dc.subject.wosBone-marrow Biopsypt_BR
dc.subject.wosAntibodiespt_BR
dc.subject.wosDiagnosispt_BR
dc.description.abstractOsteolytic lesions rarely occur in acute myeloid leukemia (AML). We reported an atypical form of the disease, with marrow fibrosis and osteolytic lesions, in a 17-year-old patient, whose main symptom was lumbar pain. Diagnosis of AML was established by bone marrow and lymph node histological analysis. Computed tomography (CT) scan and Tc-99m-MDP bone scintyscan revealed osteolytic lesions. After remission-induction, bone marrow aspirate and biopsy showed no evidence of leukemic infiltration, nevertheless bone abnormalities persisted on Tc-99m-MDP bone scintyscan, suggesting residual disease. Suspect bone areas were irradiated with symptomatic improvement and Tc-99m-MDP bone scintyscan showed the appearance of more condensed bone compared with the pre-radiotherapy pattern. Twelve months later he was readmitted to the hospital due to relapse of AML and died of sepsis within a few weeks. This report illustrates the usefulness of histological studies to establish diagnosis of AML in atypical cases, as well as the importance of CT scan and bone scintigraphy scan for the identification of osteolytic lesions. It also provides additional data as evidence that although osteolytic lesions indicate an adverse prognosis in AML, local irradiation results symptomatic relief.pt
dc.relation.ispartofHaematologiapt_BR
dc.relation.ispartofabbreviationHaematologiapt_BR
dc.publisher.cityZeistpt_BR
dc.publisher.countryHolandapt_BR
dc.publisherVsp Bvpt_BR
dc.date.issued2000pt_BR
dc.identifier.citationHaematologia. Vsp Bv, v. 30, n. 4, n. 325, n. 331, 2000.pt_BR
dc.language.isoenpt_BR
dc.description.volume30pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage325pt_BR
dc.description.lastpage331pt_BR
dc.rightsabertopt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn0017-6559pt_BR
dc.identifier.wosidWOS:000166532500009pt_BR
dc.identifier.doi10.1163/156855900300109576pt_BR
dc.date.available2014-12-02T16:29:45Z
dc.date.available2015-11-26T17:21:19Z-
dc.date.accessioned2014-12-02T16:29:45Z
dc.date.accessioned2015-11-26T17:21:19Z-
dc.description.provenanceMade available in DSpace on 2014-12-02T16:29:45Z (GMT). No. of bitstreams: 1 WOS000166532500009.pdf: 4268495 bytes, checksum: 5c1339a684a0a67f210e104ffdf09623 (MD5) Previous issue date: 2000en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:21:19Z (GMT). No. of bitstreams: 2 WOS000166532500009.pdf: 4268495 bytes, checksum: 5c1339a684a0a67f210e104ffdf09623 (MD5) WOS000166532500009.pdf.txt: 13666 bytes, checksum: 95210cf01fd772575f13fec8fa6b02d4 (MD5) Previous issue date: 2000en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69807pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/69807
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69807-
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