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Type: Artigo de periódico
Title: IL2 and TNFA gene polymorphisms and the risk of graft-versus-host disease after allogeneic haematopoietic stem cell transplantation
Author: Viel, DO
Tsuneto, LT
Sossai, CR
Lieber, SR
Marques, SBD
Vigorito, AC
Aranha, FJP
Oliveira, GB
Miranda, ECM
de Souza, CA
Visentainer, JEL
Abstract: This study aimed to analyse the association of gene polymorphisms with the outcome of allogeneic haematopoietic stem cell transplantation. We studied 122 donor/recipient pairs who received HLA-identical transplants from siblings at the Universidade Estadual de Campinas, Brazil, between June 1996 and June 2006. Donor/recipient alleles for TNFA-238 and IL2-330/+166 single-nucleotide polymorphisms (SNP) were analysed by PCR-SSP. No association was observed between the risk of acute graft-versus-host disease (GVHD) and these SNP. However, our findings suggest that the polymorphism of promoter gene TNFA-238GA is associated with the occurrence and severity of chronic GVHD. The probability of chronic GVHD in patients with GA genotype at position -238 of TNFA gene is 91.7% in contrast to 59.4% in patients with GG genotype (P = 0.038). In patients with donor GA genotype the probability of chronic GVHD is 90.8%, and 57.9% in patients with donor GG genotype (P = 0.038). The probability of extensive chronic GVHD in patients with TNFA-238GA is 91.7% compared with 46.3% in patients with TNFA-238GG (P = 0.0046). In patients with donor GA genotype at position -238 of the TNFA gene, it is 81.7%, compared with 44.5% in patients with donor GG genotype (P = 0.016). However, further studies with more patients are required to identify cytokine gene polymorphisms and their association with transplant-related complication in Brazil, particularly due to ethnic background, the relatively low power of detection of genetic markers of this study, and the complexity of the MHC region.
Country: Inglaterra
Editor: Blackwell Publishing
Citation: Scandinavian Journal Of Immunology. Blackwell Publishing, v. 66, n. 6, n. 703, n. 710, 2007.
Rights: fechado
Identifier DOI: 10.1111/j.1365-3083.2007.02021.x
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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