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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleHypertrophic lupus erythematosus: a clinicopathological study of 14 casespt_BR
dc.contributor.authorDaldon, PECpt_BR
dc.contributor.authorde Souza, EMpt_BR
dc.contributor.authorCintra, MLpt_BR
unicamp.authorState Univ Campinas, UNICAMP, Dept Dermatol, Campinas, SP, Brazil State Univ Campinas, UNICAMP, Dept Pathol, Campinas, SP, Brazilpt_BR
dc.subject.wosSquamous-cell Carcinomapt_BR
dc.subject.wosTrans-epidermal Eliminationpt_BR
dc.subject.wosActinic Comedonal Plaquept_BR
dc.subject.wosElastic Fiberspt_BR
dc.subject.wosBlack Patientspt_BR
dc.description.abstractBackground: Hypertrophic lupus erythematosus (HLE) is a distinct and rare subset of lupus erythematosus (LE). It is characterized by verrucous lesions, chronic in its course, and resistant to treatment. The purpose of this study was to identify clinical and histological characteristics of HLE. Methods: We review our experience with 14 cases of HLE identified in a group of 220 patients with different forms of LE, at the UNICAMP Hospital, between 1976 and 2002. Results: All patients presented verrucous plaques concomitantly with discoid lesions. The most common sites of involvement were the face and the arms. Histology of HLE lesions revealed pseudoepitheliomatous hyperplasia engulfing elastotic material. Elastic fibers were seen in migration throughout the epidermis. Classic features of LE were noted in all cases. Three of the patients developed hyperkeratotic papules with central keratinous plug on their arms at the previous LE sites. These lesions resemble clinically and histopathologically keratoacanthomas. In one patient, HLE lesion progressed to squamous cell carcinoma (SCC), 26 years after the onset of the disease. Conclusions: Transepithelial elimination of the elastotic material may be a feature of HLE. Some HLE lesions may present as keratoacanthoma, but classical features of LE aid the correct diagnosis. SCC may arise on a long-standing HLE lesion; therefore HLE requires clinical and histopathological follow
dc.relation.ispartofJournal Of Cutaneous Pathologypt_BR
dc.relation.ispartofabbreviationJ. Cutan. Pathol.pt_BR
dc.publisherBlackwell Munksgaardpt_BR
dc.identifier.citationJournal Of Cutaneous Pathology. Blackwell Munksgaard, v. 30, n. 7, n. 443, n. 448, 2003.pt_BR
dc.sourceWeb of Sciencept_BR
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