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Type: Artigo de periódico
Title: Frontline therapy with early intensification and autologous stem cell transplantation versus conventional chemotherapy in unselected high-risk, aggressive non-Hodgkin's lymphoma patients: A prospective randomized GEMOH report
Author: Baldissera, RC
Nucci, M
Vigorito, AC
Maiolino, A
Simoes, BP
Lorand-Metze, I
Aranha, FJP
Miranda, ECM
Pagnano, KBB
Ruiz, MA
Moraes, AAJG
De Souza, CA
Abstract: This prospective multicenter randomized trial compares conventional with early intensification with high-dose sequential chemotherapy (HDS) and autologous stem cell transplantation (ASCT) as frontline therapy in high-risk non-Hodgkin lymphomas (NHL). Newly diagnosed patients with aggressive high-risk [intermediate-high (HI) and high-risk (HR)] NHL according to the international prognosis index (IPI) were randomized to receive 12-week VACOP-B (arm A, 27 patients) or 6-week VACOP-B followed by HDS and ASCT (arm B, 29 patients). Complete remission rate was 52% in arm A and 55% in B. Nine patients (16%) died early due to progression. According to intention-to-treat, with a median follow-up of 23 months, the 5-year actuarial overall survival, progression-free survival and disease-free survival in arms A and B were 47 and 40% (p = nonsignificant), 47 and 30% (p = nonsignifi cant), and 97 and 47% (p = 0.02), respectively. Abbreviated chemotherapy followed by intensification with HDS-ASCT does not seem to be superior to conventional chemotherapy in HI/HR aggressive NHL. Copyright (C) 2006 S. Karger AG, Basel.
Subject: international prognostic index, high risk
non-Hodgkin's lymphoma, aggressive
stem cell transplantation, autologous
VACOP-B regimen
Country: Suíça
Editor: Karger
Citation: Acta Haematologica. Karger, v. 115, n. 41671, n. 15, n. 21, 2006.
Rights: fechado
Identifier DOI: 10.1159/000089460
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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