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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleFatty acid synthase expression in squamous cell carcinoma of the tongue: clinicopathological findingspt_BR
dc.contributor.authorSilva, SDpt_BR
dc.contributor.authorPerez, DEpt_BR
dc.contributor.authorNishimoto, INpt_BR
dc.contributor.authorAlves, FApt_BR
dc.contributor.authorPinto, CALpt_BR
dc.contributor.authorKowalski, LPpt_BR
dc.contributor.authorGraner, Ept_BR
unicamp.author.emailegraner@fop.unicamp.brpt_BR
unicamp.authorSilva, S. D. Perez, D. E. Graner, E. Univ Estadual Campinas, Sch Dent Piracicaba, Dept Oral Diag, BR-13414018 Sao Paulo, Brazilpt_BR
unicamp.authorNishimoto, I. N. Pinto, C. A. L. Kowalski, L. P. AC Camargo Canc Hosp, Dept Head & Neck Surg & Otolaryngol, Sao Paulo, Brazilpt_BR
unicamp.authorAlves, F. A. AC Camargo Canc Hosp, Dept Stomatol, Sao Paulo, Brazilpt_BR
dc.subjectoral squamous cell carcinomapt_BR
dc.subjectfatty acid synthasept_BR
dc.subjectoral cancerpt_BR
dc.subjectimmunohistochemistrypt_BR
dc.subject.wosHer2/neu Erbb-2 Oncogenept_BR
dc.subject.wosBreast-cancer Cellspt_BR
dc.subject.wosProstate-cancerpt_BR
dc.subject.wosImmunohistochemical Expressionpt_BR
dc.subject.wosPharmacological Inhibitorspt_BR
dc.subject.wosAntitumor-activitypt_BR
dc.subject.wosOvarian Neoplasmspt_BR
dc.subject.wosGene-expressionpt_BR
dc.subject.wosIncreased Riskpt_BR
dc.subject.wosStage-ipt_BR
dc.description.abstractBACKGROUND: Overexpression of fatty acid synthase (FAS), the cytosolic enzyme responsible for the conversion of dietary carbohydrates to fatty acids, has been reported in several human malignancies and pointed as a potential prognostic marker for some tumors. This study investigated whether FAS immunohistochemical expression is correlated with the clinicopathological characteristics of oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: The clinical features of 102 patients with OSCC of the tongue treated in a single institution were obtained from the medical records and all histopathological diagnoses were reviewed. The expression of FAS was determined by the standard immunoperoxidase technique in formalin-fixed and paraffin-embedded specimens and correlated with the clinicopathological characteristics of the tumors. RESULTS: Eighty-one cases (79.41%) were positive for FAS. Microscopic characteristics such as histological grade (P < 0.05), lymphatic permeation (P < 0.001), perineural infiltration (P < 0.05), and nodal metastasis (P < 0.02) were associated with FAS status. A significantly lower survival probability for patients with advanced clinical stage (log-rank test, P < 0.001), lymph nodes metastasis (log-rank test, P < 0.001), presence of vascular permeation (log-rank test, P = 0.05), and perineural invasion (log-rank test, P = 0.01) was observed in the studied samples. CONCLUSION: The expression of FAS in OSCC of the tongue is associated with the microscopic characteristics that determine disease progression and prognosis.pt
dc.relation.ispartofOral Diseasespt_BR
dc.relation.ispartofabbreviationOral Dis.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherBlackwell Publishingpt_BR
dc.date.issued2008pt_BR
dc.date.monthofcirculationMAYpt_BR
dc.identifier.citationOral Diseases. Blackwell Publishing, v. 14, n. 4, n. 376, n. 382, 2008.pt_BR
dc.language.isoenpt_BR
dc.description.volume14pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage376pt_BR
dc.description.lastpage382pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1354-523Xpt_BR
dc.identifier.wosidWOS:000254954200013pt_BR
dc.identifier.doi10.1111/j.1601-0825.2007.01395.xpt_BR
dc.date.available2014-07-30T17:34:41Z
dc.date.available2015-11-26T16:52:09Z-
dc.date.accessioned2014-07-30T17:34:41Z
dc.date.accessioned2015-11-26T16:52:09Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T16:52:09Z (GMT). No. of bitstreams: 2 WOS000254954200013.pdf: 324432 bytes, checksum: 63bdd83fdc9abdebe8055eec1024d63d (MD5) WOS000254954200013.pdf.txt: 35824 bytes, checksum: 198a2a7c3b25aa7dd15de55ac38345c8 (MD5) Previous issue date: 2008en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66808
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66808-
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