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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleFatty acid synthase expression in squamous cell carcinoma of the tongue: clinicopathological findingspt_BR
dc.contributor.authorSilva, SDpt_BR
dc.contributor.authorPerez, DEpt_BR
dc.contributor.authorNishimoto, INpt_BR
dc.contributor.authorAlves, FApt_BR
dc.contributor.authorPinto, CALpt_BR
dc.contributor.authorKowalski, LPpt_BR
dc.contributor.authorGraner, Ept_BR
unicamp.authorSilva, S. D. Perez, D. E. Graner, E. Univ Estadual Campinas, Sch Dent Piracicaba, Dept Oral Diag, BR-13414018 Sao Paulo, Brazilpt_BR
unicamp.authorNishimoto, I. N. Pinto, C. A. L. Kowalski, L. P. AC Camargo Canc Hosp, Dept Head & Neck Surg & Otolaryngol, Sao Paulo, Brazilpt_BR
unicamp.authorAlves, F. A. AC Camargo Canc Hosp, Dept Stomatol, Sao Paulo, Brazilpt_BR
dc.subjectoral squamous cell carcinomapt_BR
dc.subjectfatty acid synthasept_BR
dc.subjectoral cancerpt_BR
dc.subject.wosHer2/neu Erbb-2 Oncogenept_BR
dc.subject.wosBreast-cancer Cellspt_BR
dc.subject.wosImmunohistochemical Expressionpt_BR
dc.subject.wosPharmacological Inhibitorspt_BR
dc.subject.wosOvarian Neoplasmspt_BR
dc.subject.wosIncreased Riskpt_BR
dc.description.abstractBACKGROUND: Overexpression of fatty acid synthase (FAS), the cytosolic enzyme responsible for the conversion of dietary carbohydrates to fatty acids, has been reported in several human malignancies and pointed as a potential prognostic marker for some tumors. This study investigated whether FAS immunohistochemical expression is correlated with the clinicopathological characteristics of oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: The clinical features of 102 patients with OSCC of the tongue treated in a single institution were obtained from the medical records and all histopathological diagnoses were reviewed. The expression of FAS was determined by the standard immunoperoxidase technique in formalin-fixed and paraffin-embedded specimens and correlated with the clinicopathological characteristics of the tumors. RESULTS: Eighty-one cases (79.41%) were positive for FAS. Microscopic characteristics such as histological grade (P < 0.05), lymphatic permeation (P < 0.001), perineural infiltration (P < 0.05), and nodal metastasis (P < 0.02) were associated with FAS status. A significantly lower survival probability for patients with advanced clinical stage (log-rank test, P < 0.001), lymph nodes metastasis (log-rank test, P < 0.001), presence of vascular permeation (log-rank test, P = 0.05), and perineural invasion (log-rank test, P = 0.01) was observed in the studied samples. CONCLUSION: The expression of FAS in OSCC of the tongue is associated with the microscopic characteristics that determine disease progression and
dc.relation.ispartofOral Diseasespt_BR
dc.relation.ispartofabbreviationOral Dis.pt_BR
dc.publisherBlackwell Publishingpt_BR
dc.identifier.citationOral Diseases. Blackwell Publishing, v. 14, n. 4, n. 376, n. 382, 2008.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.provenanceMade available in DSpace on 2014-07-30T17:34:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2008en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:52:09Z (GMT). No. of bitstreams: 2 WOS000254954200013.pdf: 324432 bytes, checksum: 63bdd83fdc9abdebe8055eec1024d63d (MD5) WOS000254954200013.pdf.txt: 35824 bytes, checksum: 198a2a7c3b25aa7dd15de55ac38345c8 (MD5) Previous issue date: 2008en
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