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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleFamily-based association of HLA class II alleles and haplotypes with type I diabetes in Brazilians reveals some characteristics of a highly diversified populationpt_BR
dc.contributor.authorVolpini, WMGpt_BR
dc.contributor.authorTesta, GVpt_BR
dc.contributor.authorMarques, SBDpt_BR
dc.contributor.authorAlves, LIpt_BR
dc.contributor.authorSilva, MERpt_BR
dc.contributor.authorDib, SApt_BR
dc.contributor.authorGuerra, Gpt_BR
dc.contributor.authorPaulino, MFVMpt_BR
dc.contributor.authorMarini, SHVLpt_BR
dc.contributor.authorPersoli, LBLpt_BR
dc.contributor.authorCaillat-Zucman, Spt_BR
unicamp.authorUniv Campinas, Lab Histocompatibil, Hemotherapy Ctr, BR-13081970 Campinas, SP, Brazil Univ Campinas, Dept Paediat, Fac Med, BR-13081970 Campinas, SP, Brazil Univ Sao Paulo, Fac Med, Serv Endocrinol, Sao Paulo, Brazil Univ Fed Sao Paulo, Fac Med, Serv Endocrinol, Sao Paulo, Brazil Hop Necker Enfants Malad, Immunol Lab, Paris, Francept_BR
dc.subjecttype I diabetespt_BR
dc.subjectHLA associationpt_BR
dc.subjectaffected family-based control methodpt_BR
dc.subjectBrazilian populationpt_BR
dc.subject.wosGlutamic-acid Decarboxylasept_BR
dc.subject.wosIddm Patientspt_BR
dc.subject.wosMellituspt_BR
dc.subject.wosDqpt_BR
dc.subject.wosSusceptibilitypt_BR
dc.subject.wosPredispositionpt_BR
dc.subject.wosResistancept_BR
dc.subject.wosProtectionpt_BR
dc.subject.wosAntigenspt_BR
dc.subject.wosSubtypespt_BR
dc.description.abstractThe association of HLA class II haplotypes with type I diabetes was analyzed in 56 Southeastern Brazilian families using affected family-based controls (AFBAC) method. DRB1-DQA1-DQB1 alleles were determined by polymerase chain reaction/sequence-specific primer genotyping. This study first revealed the great haplotype diversity of Brazilians (65 different haplotypes even with incomplete DRB1 subtyping), probably due to the admixture of Africans genes with European and Amerindian genes in this population. The results revealed increased frequencies of the DRB1*03-DQA1*0501-DQB1*02 and DRB1*0401-DQA1*03-DQB1*0302 haplotypes in the patient group The highest risk for type I diabetes was associated with the heterozygote DRB1*03/*04 genotype as largely reported, and DRB1*03/X and DRB1*04/Y genotypes conferred a significant, but much lower disease risk. Protection from type I diabetes revealed some peculiarities in Southeastern Brazilians: a lack of significant protecting effect of the DRB1*1501-DQA1*0102-DQB1*0602 haplotype, and an apparent protection conferred by the DRB1*13-DQB1*0301, DRB1*11-DQB1*0301, and DRB1*01-DQB1*0501 two-locus haplotypes. The risk to type I diabetes in the highly diversified Southeastern Brazilians evidenced specific information to the prediction of the disease in this region of the country. (C) American Society for Histocompatibility and Immunogenetics, 2001. Published by Elsevier Science Inc.pt
dc.relation.ispartofHuman Immunologypt_BR
dc.relation.ispartofabbreviationHum. Immunol.pt_BR
dc.publisher.cityNew Yorkpt_BR
dc.publisher.countryEUApt_BR
dc.publisherElsevier Science Incpt_BR
dc.date.issued2001pt_BR
dc.date.monthofcirculationNOVpt_BR
dc.identifier.citationHuman Immunology. Elsevier Science Inc, v. 62, n. 11, n. 1226, n. 1233, 2001.pt_BR
dc.language.isoenpt_BR
dc.description.volume62pt_BR
dc.description.issuenumber11pt_BR
dc.description.firstpage1226pt_BR
dc.description.lastpage1233pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn0198-8859pt_BR
dc.identifier.wosidWOS:000172014500004pt_BR
dc.identifier.doi10.1016/S0198-8859(01)00323-8pt_BR
dc.date.available2014-11-18T21:50:12Z
dc.date.available2015-11-26T16:59:29Z-
dc.date.accessioned2014-11-18T21:50:12Z
dc.date.accessioned2015-11-26T16:59:29Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T16:59:29Z (GMT). No. of bitstreams: 2 WOS000172014500004.pdf: 87364 bytes, checksum: e2b19273d65f372a261de7007bc6fe5e (MD5) WOS000172014500004.pdf.txt: 30659 bytes, checksum: 639eecb9be10618e335137a35af964a0 (MD5) Previous issue date: 2001en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66753pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/66753
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66753-
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